Article

Nansen Neuroscience Lectures 2015

The Nansen Neuroscience Lectures (NNL) are organized in conjunction with Fridtjof Nansen's birthday to commemorate his fundamental contribution to neuroscience. This year professor Bernardo Sabatini from Harvard University is invitedJoin us October 12th! 

When: Monday 12th October 2015 at 11:30 – 13:00

Where: The Norwegian Academy of Science and Letters – DNVA, Drammensv 78, 0271 Oslo

Why: The Nansen Neuroscience Lectures (NNL) are organized in conjunction with Fridtjof Nansen's birthday to commemorate his fundamental contribution to neuroscience*. The NNL are given by speakers selected from the top tier of neuroscience research.

Admission: Open to public, no charge

11:30 – 12:00 Coffee and refreshments, mingling

12:00 – 12:03 Opening by Kirsti Strøm Bull, President of The Norwegian Academy of Science and Letters

12:03 – 12:06 Introduction by Linda H. Bergersen, University of Oslo

12:06 – 12:46 Lecture by Bernardo L. Sabatini, Harvard University

12:46 – 13:00 Discussion and questions from the audience, moderator Jon Storm-Mathisen

Bernardo Luis Sabatini

Strange synapses – implications for biology, disease, and therapy

Affiliation:

Sabatini Lab
Howard Hughes Medical Institute
Harvard Medical School Dept of Neurobiology
Warren Alpert 347-354
200 Longwood Ave, Boston, MA 02115, USA
bernardo_sabatini@hms.harvard.edu

http://sabatini.hms.harvard.edu/
http://www.hhmi.org/scientists/bernardo-l-sabatini

Abstract

Neurons communicate via specialized contact points called synapses at which neurotransmitters are released and activate specific receptor proteins. Synaptic activity is responsible for transmitting information throughout the brain and regulation of synapses is thought to be the biological substrate underlying learning and memory formation. Here we present recent data from our laboratory on the nature of neurotransmission in the basal ganglia, a phylogenetically old and evolutionarily conserved brain area that mediates coordinated and goal-oriented motor action. In humans, dysfunction of the basal ganglia underlies many neuropsychiatric disorders such as Parkinson¹s, Tourette¹s, drug addiction, and Huntington's. We find that synapses within this region have unique cell biological and signaling properties such that they target distinct neuronal populations with different neurotransmitters. Our findings reveal an additional level of complexity in neuronal cell biology and network organization with crucial implications for the treatment of human disease.

Biography

Professor Bernardo Sabatini is based at Harvard Medical School, and is also a Howard Hughes Medical Institute ?HHMI? Investigator. His laboratory seeks to uncover the mechanisms of synapse and circuit plasticity that permit new behaviors to be learned and refined. They are interested in the developmental changes that occur after birth that make learning possible as well as in the circuit changes that are triggered by the process of learning. Lastly, they examine how perturbations of these processes contribute to human neuropsychiatric disorders such as Tuberous Sclerosis Complex and Parkinson's disease.

Organizers

Linda H Bergersen and Jon Storm-Mathisen in cooperation with the University of Oslo, the Nansen Neuroscience Network (NNN), and the Norwegian Academy of Science and Letters (DNVA).

Visit DNVA's website for more information